Plant Reactome and PubChem: The Plant Pathway and (Bio)Chemical Entity Knowledgebases.

TitlePlant Reactome and PubChem: The Plant Pathway and (Bio)Chemical Entity Knowledgebases.
Publication TypeJournal Article
Year of Publication2022
AuthorsGupta, P, Naithani, S, Preece, J, Kim, S, Cheng, T, D'Eustachio, P, Elser, J, Bolton, EE, Jaiswal, P
JournalMethods Mol Biol
Date Published2022
KeywordsDatabases, Factual, Knowledge Bases, Metabolic Networks and Pathways, Plants, Proteins

Plant Reactome ( and PubChem ( ) are two reference data portals and resources for curated plant pathways, small molecules, metabolites, gene products, and macromolecular interactions. Plant Reactome knowledgebase, a conceptual plant pathway network, is built by biocuration and integrating (bio)chemical entities, gene products, and macromolecular interactions. It provides manually curated pathways for the reference species Oryza sativa (rice) and gene orthology-based projections that extend pathway knowledge to 106 plant species. Currently, it hosts 320 reference pathways for plant metabolism, hormone signaling, transport, genetic regulation, plant organ development and differentiation, and biotic and abiotic stress responses. In addition to the pathway browsing and search functions, the Plant Reactome provides the analysis tools for pathway comparison between reference and projected species, pathway enrichment in gene expression data, and overlay of gene-gene interaction data on pathways. PubChem, a popular reference database of (bio)chemical entities, provides information on small molecules and other types of chemical entities, such as siRNAs, miRNAs, lipids, carbohydrates, and chemically modified nucleotides. The data in PubChem is collected from hundreds of data sources, including Plant Reactome. This chapter provides a brief overview of the Plant Reactome and the PubChem knowledgebases, their association to other public resources providing accessory information, and how users can readily access the contents.

Alternate JournalMethods Mol Biol
PubMed ID35037224
PubMed Central ID5509230
Grant ListP41 HG003751 / HG / NHGRI NIH HHS / United States
U54 GM114833 / GM / NIGMS NIH HHS / United States