TitlePreparation of water soluble carbon nanotubes and assessment of their biological activity in embryonic zebrafish.
Publication TypeJournal Article
Year of Publication2013
AuthorsAdenuga, AA, Truong, L, Tanguay, RL, Remcho, VT
JournalInt J Biomed Nanosci Nanotechnol
Volume3
Issue1-2
Pagination38-51
Date Published2013 Jan 01
ISSN1756-0799
Abstract

Carbon nanotubes (CNTs) are currently one of the most important classes of nanomaterials with unique properties sparking off numerous applications in many fields, including electronics, material science and medicine. However, applications of CNTs in medicine and other biological fields are hampered by their insolubility in aqueous media and concerns regarding toxicity. In this study, seven types of CNTs, including two single-walled, one double-walled, and four multi-walled, were evaluated for possible toxicological effects. Soluble CNTs were prepared by treatment with a mixture of acids (DSO and DNO), washed with Milli-Q water and oven dried. Transmission electron microscopy, thermal gravimetric analysis, and other techniques were used to characterize the prepared CNTs. CNT toxicity was assessed using the embryonic zebrafish. Results showed that none of the CNTs studied caused significant adverse developmental effects. These results support the potential safe use of CNTs as components of indwelling medical devices and drug delivery tools.

DOI10.1504/IJBNN.2013.054514
Alternate JournalInt J Biomed Nanosci Nanotechnol
PubMed ID25750663
PubMed Central IDPMC4349379
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States